Laboratory of Experimental Pharmacology and Toxicology
RESEARCH GROUP MEMBERS
1 Giovanni Brambilla
2 Antonietta Martelli
3 Luigi Robbiano
4 Francesca Mattioli
5 Marzia Gosmar
6 Claudia Garbero
7 Valeria Manfredi
8 Debora Baroni
AFFILIATION
1 Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Italy
GROUP DATA
Address University of Genoa, DI.M.I., Division of Pharmacology, Viale Benedetto XV 2 , I-16132 Genoa, Italy
Phone +39-0103538850
Fax +39-0103538232
E-mail farmdimi@unige.it
Web Site 
RESEARCH TOPICS
1 1) genotoxic/carcinogenic activity of drugs and more generally of chemical agents
2) development and validation of sensitive short-term in vitro and in vivo assays to be used for a reliable assessment of such an activity
2 Pharmacokinetic studies, and analysis of the correlation between drug use and guidelines indications.
EDUCATION IN TOXICOLOGY
1 Ph.D in Pharmacology and Toxicology. School of Specialization in Medical Toxicology
ASSISTANCE ACTIVITY
1 Evaluation of the pharmacokinetic behaviour of drugs in humans.
COLLABORATIONS
1 With Clinical Departments of the Faculty of Medicine of the University of Genoa, Italy
PUBLICATIONS
1 F. Torre, F. Mattioli, N. Campo, A. Delfino, M. Basso, N. Peli, A. Martelli, A. Picciotto. Serum lamivudine levels in the presence of a lamivudine-resistant HBV mutant. Digestive and Liver Disease 36: 677-681, 2004.
2 I. Vezzana, E. Terranova, F. Mattioli, F. Sparatore. Aromatic Schiff bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives as antiinflammatory agents. Arkivoc: 364-374, 2004.
3 L. Robbiano, A. Martelli, G. Brambilla. The questionable use of antihypertensive drugs in the Italian Liguria region in the year 2003. Eur. J. Clin. Pharmacol. 61: 319-320, 2005.
4 F. Mattioli, A. Martelli, C. Garbero, M. Gosmar, V. Manfredi, F.P. Mattioli, G. Torre, G. Brambilla. DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens. Toxicology and Appl. Pharm. 203: 99-105, 2005.
5 G. Brambilla, A. Martelli. Keynote comment: nitrosatable drugs, cancer, and guidelines for genotoxicity. The Lancet Oncology, v. 6: 538-539, 2005.
6 L. Robbiano. A. Martelli, G. Brambilla. Discrepancies between use of antihypertensive drugs and guidelines indications: pharmacoeconomic implications. Journal of Human Hypertension 19: 819-822, 2005.
7 F. Mattioli, A. Curotto, V. Manfredi, M. Gosmar, C. Garbero, C. Ambruosi, G. Carmignani, A. Martelli. Intravescical Gemcitabine in Superficial Bladder Cancer: a Phase II Safety, Efficacy and Pharmacokineticl Study. Anticancer Res. 25: 2493-2496, 2005.
  Ultimo aggiornamento: Dicembre 2005