Nerviano Medical Science srl
Pre-Clinical Development Business Unit
RESEARCH GROUP MEMBERS
1 Marco Brughera
2 Pietro Grossi
3 Claudio Bernardi
4 Paolo Colombo
5 Mario Monshouwer
6 Andrea Terron
7 Christopher James
8 Kjell Gunnarsson
9 Maurizio Rocchetti
10 Jan Klapwijk
11 Claudio Arrigoni
12 Italo Poggesi
13 Anna Rossi
14 Goran Westerberg
AFFILIATION
1 Nerviano Medical Sciences Preclinical Development
GROUP DATA
Address Via L.Pasteur, 10 – 20014 Nerviano MI ITALY
Phone +39-0331581181
Fax +39-0331581202
E-mail marco.brughera@nervianoms.com
Web Site www.nervianoms.it
RESEARCH TOPICS
1 Attrition reducing technologies to support drug candidate selection
2 "Omics" technologies to assess mechanism of toxicity
EDUCATION IN TOXICOLOGY
SERVICES
1 Regulatory ADMET; specific expertise in anticancer drugs; in vitro and in vivo safety pharmacology services; bioanalysis; expertise in infusion studies in a broad range of animal species; drug disposition; preparation of full packages for first-in-man; repro-toxicology expertise
COLLABORATIONS
1 University of Milan
2 University of Pavia
3 Karolinska Institute (Sweden)
4 IEO, Milan
PUBLICATIONS
1 Moneta D, Geroni C, Valota O, Grossi P, de Jonge MJA; Brughera M et al. (2003). Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3'-deamino-3'-aziridinyl-4'- methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation. EurJ of Cancer 39(5), 675-683.
2 de Kanter R, Monshouwer N, Meijer D, Groothuis G (2002). Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with specialreference to non-hepatic tissues. Curr Drug Metab. 3(1):39-59. Review.
3 Della Torre P, Podesta A, Imondi AR, Moneta D, Sammartini U, Arrigoni C, Terron A, Brughera M (2001). PNU-159548, a novel cytotoxic antitumor agent with a low cardiotoxic potential. Cancer Chemother and Pharmacol 47(4), 355-60.
4 Colombo P, Gunnarsson K, Iatropoulos M, Brughera M (2001). Toxicological testing of cytotoxic drugs (Review). Int J of Oncol 19(5), 1021-1028.
5 Beltrame D, di Salle E, Giavini E, Gunnarsson K, Brughera M (2001). Reproductive toxicity of exemestane, an antitumoral aromatase inactivator, in rats and rabbits. Reproductive Toxicology 15(2), 195-213.

  Ultimo aggiornamento: Dicembre 2005