| Laboratory of Molecular Pathology |
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| RESEARCH GROUP MEMBERS |
| 1 | Lavinia Cantoni |
| 2 | Milena Rizzardini |
| 3 | Silvia Tartari |
| 4 | Giuseppina D'Alessandro |
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| AFFILIATION |
| 1 | Istituto di Ricerche Farmacologiche Mario Negri |
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| RESEARCH TOPICS |
| 1 |
Mechanisms of oxidative stress in drug toxicity
and diseases |
| 2 |
Cytochrome P-450 enzymes' induction |
| 3 |
Mechanisms of motor neuron degeneration |
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| EDUCATION IN TOXICOLOGY |
| 1 | L.C. is a teacher of the three year course for graduates leading to a diploma as "Pharmacological Research Specialist" held at the "Mario Negri Institute" as part of the Lombardy Region's professional training schemes. |
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| COLLABORATIONS |
| 1 | Centro Anemie Congenite, Ospedale Maggiore, Milano |
| 2 | Lab. Neurobiologia Sperimentale, IRCCS Fondazione "Istituto C. Mondino" |
| 3 | Dip. di Farmacologia Medica, Università degli Studi di Milano, Milano |
| 4 | Dip. degli Studi Pre-clinici, Università degli Studi di Milano, Milano |
| 5 | Dept. Biol.Chem., The Alexander Silberman Inst. Life Sci., The Hebrew Univ. Jerusalem, Israel |
| 6 | Depart. De Bioquimica, Fac Medicina/Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain |
| 7 | Biologia Cellular, Fac de Ciences Biologiques, Università di Valencia, Spain |
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| PUBLICATIONS |
| 1 | Babetto E, Mangolini A, Rizzardini M, Lupi M, Conforti L, Poletti A, Rusmini P, Cantoni L (2005) A novel tool for the study of motor neuron diseases: an NSC-34-tTA cell line for tetracycline-regulated gene expression. Mol. Brain Res. 140, 63-72. |
| 2 |
Rizzardini M, Mangolini A, Lupi M, Ubezio P,
Bendotti C, Cantoni L (2005). Low levels of ALS-linked Cu/Zn superoxide
dismutase increase the production of reactive oxygen species and
cause mitochondrial damage and death in motor neuron-like cells.
J. Neurol. Sci. 232, 95-103. |
| 3 |
Beghi E, Mennini T, Cantoni L, Bendotti C.
(2004). Basic and clinical research on amyotrophic lateral sclerosis
and other motor neuron disorders in Italy: recent findings and achievements
from a network of laboratories. Neurol. Sci. 25 Suppl 2, S41-60. |
| 4 | Cantoni L, Rozio M, Mangolini A, Hauri L, Caccia S (2003). Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse. Toxicol Sci 75, 25-30. |
| 5 | Rizzardini M, Lupi M, Bernasconi S, Mangolini A, Cantoni L (2003). Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. J Neurol Sci 207, 51-58. |
| 6 | Cantoni L,Valaperta R,.Ponsoda X, Castell J.V, Barelli D, Rizzardini M, Mangolini A, Hauri L, Villa P (2003). Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. J Hepatol 38, 776-783. |
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