RESEARCH GROUP MEMBERS
1 Orazio Cantoni
2 Andrea Guidarelli
3 Letizia Palomba
4 Ilaria Tommasini
5 Liana Cerioni
6 Elisa Carloni
AFFILIATION
1 Institute of Pharmacology and Pharmacognosy, University of Urbino
GROUP DATA
Address Via S. Chiara, 27, 61029 Urbino, Italy
Phone +39-0722303523
Fax +39-0722303523
E-mail cantoni@uniurb.it
Web Site 
RESEARCH TOPICS
1 Mechanisms of cytotoxicity mediated by reactive nitrogen/oxygen species
EDUCATION IN TOXICOLOGY
COLLABORATIONS
1 Prof. Emilio Clementi (Univ. Calabria, Rende)
2 Prof. Marco Colasanti (Univ. Roma III, Rome).
3 Prof. Enzo Nisoli (Univ. of Brescia, Brescia)
4 Prof. Bernhard Brüne (Univ. Johann Wolfgang Goethe, Frankfurt, Germany).
PUBLICATIONS
1 Guidarelli A, Cerioni L, Tommasini I, Fiorani M, Brüne B, Cantoni O. (2005). Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite. Free Rad Biol Med 39:1638-1649.
2 Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO. (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314-317.
3 Cantoni O, Guidarelli A, Palomba L, Fiorani M. (2005) U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism. Mol Pharmacol 67:1399-1405.
4 Palomba L, Persichini T, Mazzone V, Colasanti M, Cantoni O. Inhibition of nitric oxide synthase I (NOS-I)-dependent nitric oxide production by lipopolysaccharide plus interferon-g is mediated by arachidonic acid. Effects on NFKB activation and late inducile NOS expression. J Biol Chem 279:29895-29901.
5 Tommasini I, Cantoni O. (2004). Dexamethasone promotes toxicity in U937 cells exposed to otherwise non-toxic concentrations of peroxynitrite: pivotal role for lipocortin 1 mediated inhibition of cytosolic phospholipase A2. Mol Pharmacol 65:964-972.
6 Palomba L, Bianchi M, Persichini T, Magnani M, Colasanti M, Cantoni O. (2004). Downregulation of nitric oxide formation by cytosolic phospholipase A2-released arachidonic acid. Free Rad Biol Med 36:319-329.
7 Tommasini I, Sestili P, Guidarelli A, Cantoni O. (2002). Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death. Cell Death Diff 9:1368-1376.

  Ultimo aggiornamento: Dicembre 2005