Department of Toxicology
RESEARCH GROUP MEMBERS
1 Gianfranco Caselli
AFFILIATION
1 Rottapharm SpA
GROUP DATA
Address Via Valosa di Sopra 9, 20052 Monza (MI)
Phone +39-0397390335
Fax +39-0397390312
E-mail gianfranco.caselli@rotta.com
Web Site www.rotta.com
RESEARCH TOPICS
1 Drug discovery and development
EDUCATION IN TOXICOLOGY
1 Post-degree Specialization in Toxicology (Milan University, Prof Paoletti)
COLLABORATIONS
1 The activity of the group consists mainly in coordinating the experiments performed by different CROs: Pharmasafe, Chiman, RTC (I), RCC (CH), Sequani, HLS, Inveresk, Quintiles (UK), CERB (FR), Notox (NL), BioTest, Quinta-Analytica (CZ), MDS
PUBLICATIONS
1 Losi G, Lanza M, Makovec F, Artusi R, Caselli G, Puia G (2005) Functional in vitro characterization of CR 3394: A novel voltage dependent N-methyl-d-aspartate (NMDA) receptor antagonist. Neuropharmacology. Oct 14; [Epub ahead of print].
2 Ferrari F, Mennuni L, Caselli GF, Zanelli T, Makovec F (2004) Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activityEur J Pharmacol 504: 223- 233.
3 Bossu` P, Neumann D, Del Giudice E, Ciaramella A, Gloaguen I, Fantuzzi G, Dinarello CA, Di Carlo E, Musiani P, Meroni PL, Caselli GF, Ruggiero P, Boraschi D (2003). IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. PNAS 100(24):14181-14186.
4 Michieli P,Cavassa S, Basilico C, De Luca A, Mazzone M, Asti C, Chiusaroli R, Guglielmi M, Bossù P, Colotta F, Caselli G, Comoglio PM (2002). An Hgf-Msp chimaera disassociates the trophic properties of scatter factors from their pro-invasive activity. Nature. Biotechnology 20:488-95.
5 Pagliei S, Ghezzi P, Bizzarri C, Sabbatini V, Frascaroli G, Sozzani S, Caselli G, Bertini R (2002). Thioredoxin specifically cross-desensitizes monocytes to MCP-1 Eur Cytokine Netw 13(2):261-7.
6 Ceschel GC, Maffei P, Porzio S, Melillo G, Caselli GF, Dragani MC, Gentile MM, Clavenna G. (2002). In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers. drug deliv 9(4):259-63.
7 Brandolini L, Intilangelo A, Caselli G, Bertini R (2001). Role of tumor necrosis factor-alpha in endotoxin-induced lung parenchymal hyporesponsiveness in mice. Biochem Pharmacol 62:1141-4.

  Ultimo aggiornamento: Dicembre 2005