| Oxidative Stress Laboratory |
|
|
| RESEARCH GROUP MEMBERS |
| 1 |
Mario Comporti |
| 2 |
Cinzia Signorini |
| 3 |
Concetta Gardi |
| 4 |
Lucia Ciccoli |
| 5 |
Emilia Maellaro |
|
|
| AFFILIATION |
| 1 | Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena |
|
|
|
|
|
| RESEARCH TOPICS |
| 1 |
Evaluation of oxidative stress in human and
experimental pathology by means of gas-mass determinations of F2-isoprostanes.
Role of isoprostanes in fibrotic processes |
| 2 |
Oxidative stress and erythrocyte ageing, oxidative
stress, iron release, protein oxidation and formation of Band 3
dimers as markers of erythrocyte ageing |
|
|
| ASSISTANCE ACTIVITIES |
| 1 |
Determination of F2-isoprostanes in plasma
and other biological fluids, in various human pathologies |
| 2 |
Evaluation of aged erythrocytes in a number
of human pathologies (Premature newborns, hemolytic anemias, Diabetes,
etc) |
|
|
| EDUCATION IN TOXICOLOGY |
| 1 | Courses of General Pathology in Medicine, Biology and Farmacy Faculties of the University of Siena, and in Ph.D. and specialization courses. |
| 2 | Seminars on free radicals and oxidative stress in pathology. |
|
|
| COLLABORATIONS |
| 1 | University of Parma |
| 2 | University of Pisa |
| 3 | University of Padova |
| 4 | University of Kyoto |
| 5 | University of Buenos Aires |
|
|
| PUBLICATIONS |
| 1 |
Rossi V, Leoncini S, Signorini C, Buonocore
G, Paffetti P, Tanganelli D, Ciccoli L, Comporti M Oxidative stress
and autologous IgG binding to band 3 dimers in newborn erythrocytes.
(in press). |
| 2 |
Comporti M, Arezzini B, Signorini C, Sgherri
C, Monaco B, Gardi C (2005) F(2)-isoprostanes stimulate collagen
synthesis in activated hepatic stellate cells: a link with liver
fibrosis? Lab Invest 85(11):1381-91. |
| 3 |
Signorini C, Comporti M, Giorgi G (2003). Iron
traps tandem mass spectrometry determination of F2-isoprostanes.
J Mass Spectrom 38(10):1067-1074. |
| 4 |
Ciccoli L, Rossi V, Leoncini S, Signorini C,
Paffetti P, Bracci R, Buonocore G, Comporti M (2003). Iron release
in erythrocytes and plasma non protein-bound iron in hypoxic and
non hypoxic newborns. Free Rad Res 37:51-58. |
| 5 |
Gardi C, Arezzini B, Fortino V, Comporti M
(2002). Effect of free iron on collagen synthesis, cell proliferation
and MMP-2 expression in rat hepatic stellate cells. Biochem Pharmacol
64:1139-1145. |
| 6 |
Comporti M, Signorini C, Buonocore G, Ciccoli
L (2002). Iron release, oxidative stress and erythrocyte ageing.
Free Rad Biol Med 32:568-576. |
| 7 |
Del Bello B, Valentini MA, Zunino F, Comporti
M, Maellaro E (2001). Cleavage of Bcl-2 in oxidant- and cisplatin-induced
apoptosis of human melanoma cells. Oncogene 20:4591-4595. |
|