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| RESEARCH GROUP MEMBERS |
| 1 | Maria Enrica Fracasso |
| 2 | Paola Franceschetti |
| 3 | Denise Doria |
| 4 | Michele Piazza |
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| AFFILIATION |
| 1 | Department of Medicine and Public Health, Section of Pharmacology. |
| 2 | Medical School, University of Verona |
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| GROUP DATA |
| Address | Policlinico GB Rossi, P.le LA Scuro 10 - 37134 Verona, Italy |
| Phone | +39-0458027606/11 |
| Fax | +39-045581111 |
| E-mail |
mariaenrica.fracasso@univr.it |
| Web Site | |
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| RESEARCH TOPICS |
| 1 |
Human genetic polymorphysms of CYP450 metabolism
of I and II phase |
| 2 |
Mutagenic tests: fluctuation test and Ames
test on S. typhimurium (TA 1537; TA 1538; TA 98; TA 100; YG 1021;
YG 1024) and E. coli (WP2; WP2 uvrA-) with and without metabolic
system. |
| 3 |
Mechanisms by which drugs or environmental
agents modulate cell signalling: reactive oxygen species, glutathione,
down- up-regulation of protein kinase C isoenzymes |
| 4 |
DNA damage by Single Cell Gel Electrophoresis,
neutral and alkaline version (Comet Assay) in lymphocytes, urothelial
cells, oral mucosa cells |
| 5 |
Analysis of DNA repair phenotype by the comet
assay and enzymes in lymphocytes |
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| ASSISTANCE ACTIVITIES |
| 1 | Responsible of Toxicological Advisory Group Working in the Hospital of Verona |
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| EDUCATION IN TOXICOLOGY |
| 1 | Toxicology courses for MD degree: Toxicology and Pharmacology Special course on Abuse of Drugs |
| 2 | Toxicology and Pharmacology for Nursing degree |
| 3 | Toxicology and Pharmacology for Techniques in Biomedical Laboratory degree |
| 4 | Toxicology for Ph.D – Biotechnologies in Biomedical Science |
| 5 | Specialization in Occupational Health |
| 6 | Specialization in Hygiene and Preventive Medicine |
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| COLLABORATIONS |
| 1 |
University of Verona: Occupational Health,
Prof. L. Perbellini; Dep. of Pathology, Prof. F. Bonetti; Dep. of
Biochem. Science and Surgery, Prof. G. Talamini; Dep. of Dentistry,
Prof. F. Faccioni; Dep. of Anatomy, Prof. C. Zancanaro. |
| 2 |
University of Bologna: Dep. of Pharmacology,
Prof. P. Hrelia |
| 3 |
University of Bari: Dep. of Med. And Public
Health, Prof. L. Soleo |
| 4 |
University of Siena: Dep. of Pharmacology,
Prof. M. Valoti |
| 5 |
University of Napoli: Dep. of Prev. Medical
Science, Prof. M. Manno |
| 6 |
University of Padova: Dep. Occupational Health,
Prof. G. Bartolucci |
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| PUBLICATIONS |
| 1 | Fracasso ME, Franceschetti P, Doria D, Talamini G, Bonetti F (2004). DNA breaks as measured by the alcaline comet assay in exfoliated cells as compared to voided urine cytology in the diagnosis of bladder cancer: a study of 105 patients. Mutation Res 564: 57-64. |
| 2 | Faccioni F, Franceschetti P, Cerpelloni M, Fracasso ME (2003). In vivo study on metal release from fixed orthodontic appliances and DNA damage in oral mucosa cells. Am J Orthod Dentofacial Orthoped 124/6:687-693. |
| 3 | Franceschetti P, Perbellini L, Tieghi S, Fracasso ME (2002). Comparative investigations in Single Cell Gell Electrophoresis (Comet Assay) in lymphocytes and the Ames-fluctuation test in the urine of workers of a rubber factory. Cancer Detect Prev 26(1):247. |
| 4 | Fracasso ME, Perbellini L, Soldà S, Talamini G, Franceschetti P (2002). Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C. Mutation Res 515(2):159-169. |
| 5 | Fracasso ME, Franceschetti P., Doria D., Quintarelli E., Noris P., Brugnone F., Romeo L. (2004). Valutazione di danno e riparo del DNA mediante comet assay in linfociti di soggetti non-fumatori ed ex-fumatori esposti a fumo passivo. G Ital Med Lav Erg 26(4): 61-62. |
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