Pharmacology and toxicology of autacoids
clinical toxicology and medicine of drug addiction
RESEARCH GROUP MEMBERS
1 Emanuela Masini
2 Pier Francesco Mannaioni
3 Alfredo Vannacci
4 Cosimo Marzocca
5 Lucia Giannini
6 Francesca Fabrizi
7 Caterina Uliva
8 Rosanna Mastroianni
CLINICAL STAFF
9 Flavio Moroni
10 Primo Botti
11 Bassam Dannaoul
12 Sandro Peruzzi
13 Laura Caramelli
14 Alessandra Pistelli
15 Francesco Gambassi
16 Alessandra Ieri
17 Carlo Smorlesi
18 Brunella Occupati
AFFILIATION
1 University of Florence, Department of Preclinical and Clinical Pharmacology
2 Azienda Ospedaliera Universitaria Careggi
GROUP DATA
Address Viale Pieraccini 6, 50139, Firenze
Phone +39-0554271233
Fax +39-0554271280
E-mail emanuela.masini@unifi.it
Web Site www.pharm.unifi.it/
RESEARCH TOPICS
1 Evaluation of endogenous and exogenous cannabinoids and green tea poliphenols as modulators of immuno-allergic responses
2 Validation of new therapeutic protocols for the therapy of drug addiction
3 Study of brain metabolism (FDG-PET) of drug addicts and its correlations with clinical and psychopathological features (craving)
4 Modulation of the cellular response of the inflammatory cells by carbon monoxide and nitric oxide
5 Role of nitric oxide synthase (NOS) cyclooxygenase (COX) and lipooxygenase (LOX) in the regulation of angiogenesis and tumor growth and myocardial ischaemia and reperfusion
6 Evaluation of the anti-inflammatory effects of low-molecular weight bioheparins
EDUCATION IN TOXICOLOGY
1 Pharmacology and Toxicology courses for: University degrees: 1. Medicine 2. Biotechnology 3. Biomedical Laboratory technician 4. Prevention technician
2 Masters: 1. Civil Protection 2. Nursing assistance in clinical area 3. NBC Medicine
3 Post-degree Specialization Schools: 1. Medical Toxicology 2. Clinical and Applied Pharmacology 3. Sports Medicine 4. Occupational Medicine 5. Medical Oncology 6. Allergology and Clinical Immunology
SERVICES
1 ASSISTANCE ACTIVITIES
The Toxicology Unit is a joint structure between the University of Florence and the Careggi General Hospital. The Unit consists in two sections: a) an In-Patient Service, 24hrs/day, and b) an Out-Patient Service. The assistance is directed towards diagnosis and treatment of acute and chronic non-professional intoxications
2 A Poisoning Control Center is active 24hrs/day, and a Perinatal Toxicological Advisory Service operates three times a week
COLLABORATIONS
1 William Harvey Research Institute, Saint Bartholomew’s Medical College, University of London, London
2 Departments of Pulmonary and Critical Care Medicine, and Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
3 Division of Pulmunary, Critical Care and Occupational Medicine, Department of Internal Medicine, S. Louis University, S Louis, USA
4 Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Florence, Italy
5 Inserm U388, IFR3, Institut Louis Bignard CHU Rangueil, Tulouse France
PUBLICATIONS
1 Bianchi P, Kunduzova O, Masini E, Cambon C, Bani D, Raimondi L, Seguelas MH, Nistri S, Colucci W, Leducq N and Parini A. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation 112: 3297-3305, 2005.
2 Cianchi F, Cortesini C, Schiavone N, Perna F, Magnelli L, Fanti E, Bani D, Messerini L, Fabbroni V, Perigli G, Capaccioli S and Masini E. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin Cancer Res 11: 6807-6815, 2005.
3 Perna AM, Masini E, Nistri S, Briganti V, Chiappini L, Stefano P, Bigazzi M, Pieroni C, Bani ST and Bani D. Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model. FASEB J 19: 1525-1527, 2005.
4 Perna AM, Masini E, Nistri S, Bani ST, Bigazzi M and Bani D. Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction. Ann N Y Acad Sci 1041: 431-433, 2005.
5 Mollace V, Muscoli C, Masini E, Cuzzocrea S and Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 57: 217-252, 2005.
6 Dani C, Masini E, Bertini G, di Felice AM, Pezzati M, Ciofini S, Rossetti M, Gallori G, Ciuti R, Buonocore G, Paffetti P, Mannaioni PF and Rubaltelli FF. Role of heme oxygenase and bilirubin in oxidative stress in preterm infants. Pediatr Res 56: 873-877, 2004.
7 Suzuki Y, Masini E, Mazzocca C, Cuzzocrea S, Ciampa A, Suzuki H and Bani D. Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. J Pharmacol Exp Ther 311: 1241-1248, 2004.
  Ultimo aggiornamento: Dicembre 2005