Biochemical Pharmacology and Technical Scientific
Advice Coordination Unit
RESEARCH GROUP MEMBERS
1 Annarita Meneguz
2 Francesca Cometa
3 Paola Lorenzini
4 Stefano Fortuna
5 Maria Teresa Volpe
6 Maria Rosaria Varì
7 Laura Parisi
AFFILIATION
1 Pharmacological Department Istituto Superiore di Sanità
GROUP DATA
Address Viale Regina Elena 299 00161 Roma
Phone +39-0649902880
Fax +39-0649387104
E-mail annamene@iss.it
Web Site  
RESEARCH TOPICS
1 Neurotoxicity
2 Metabolism
3 Safety Pharmacology
4 Regulator toxicity
5 Safety pharmacology (preclinical dossier assessment)
6 Radiopharmaceuticals
SERVICES
1 GLP Inspections
2 GMP Inspections
EDUCATION IN TOXICOLOGY
COLLABORATIONS
1 OECD
2 Saftey Working Party of EMEA
3 ECVAM
4 AIFA
5 Ministero della Salute
PUBLICATIONS
1 Coecke S, Blaauboer BJ, Elaut G, Freeman S, Freidig A, Gensmantel N, Hoet P, Kapoulas VM, Ladstetter B, Langley G, Leahy D, Mannens G, Meneguz A, Monshouwer M, Nemery B, Pelkonen O, Pfaller W, Prieto P, Proctor N, Rogiers V, Rostami-Hodjegan A, Sabbioni E, Steiling W, van de Sandt JJ. Toxicokinetics and metabolism. Altern Lab Anim. 2005 Jul;33 Suppl 1:147-75.
2 Prieto P, Clemedson C, Meneguz A, Pfaller W, Sauer UG, Westmoreland C.Subacute and subchronic toxicity. Altern Lab Anim. 2005 Jul;33 Suppl 1:109-16.
3 Gribaldo L, Gennari A, Blackburn K, Clemedson C, Deguercy A, Meneguz A, Pfaller W, Ruhdel I. Acute toxicity.Altern Lab Anim. 2005 Jul;33 Suppl 1:27-34.
4 Di Consiglio E, Meneguz A, Testai E.Organophosphorothionate pesticides inhibit the bioactivation of imipramine by human hepatic cytochrome P450s. Toxicol Appl Pharmacol. 2005 Jun 15;205(3):237-46.
5 Cometa MF, Lorenzini P, Fortuna S, Volpe MT, Meneguz A, Palmery M.In vitro inhibitory effect of aflatoxin B1 on acetylcholinesterase activity in mouse brain. Toxicology. 2005 Jan 5;206(1):125-35.
6 Buratti FM, D'Aniello A, Volpe MT, Meneguz A, Testai E. Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms.Drug Metab Dispos. 2005 Mar;33(3):295-302. Epub 2004 Nov 22.
7 Ricceri L, Markina N, Valenzano A, Fortuna S, Cometa MF, Meneguz A, Calamandrei G (2003). Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol Appl Pharmacol 191:189-201.

  Ultimo aggiornamento: Dicembre 2005