| COLLABORATIONS |
| 1 | Ian Blair (Dept. of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA) |
| 2 | Gaetano Cairo (Istituto di Patologia Generale, Facolta’ di Medicina e Chirurgia, Universita' di Milano) |
| 3 | Luca Gianni (Divisione di Oncologia Medica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano) |
| 4 | Lawrence J Marnett (Department of Biochemistry and Molecular Toxicology, Vanderbilt University, Nashville, TN, USA) |
|
| PUBLICATIONS |
| 1 |
Minotti G, Menna P, Salvatorelli E, Cairo G,
Gianni L (2004) The anthracyclines : Molecular advances and pharmacological
developments in antitumor activity and cardiotoxicity Pharmacol.
Rev. 56: 185-229. |
| 2 |
Corna G, Santambrogio P, Minotti G, Cairo (2004)
Doxorubicin paradoxically protects cardiomyocytes against iron-mediated
toxicity: Role of reactive oxygen species and ferritin. J. Biol.
Chem. 279: 13738-13745. |
| 3 |
Cartoni A, Menna P, Salvatorelli E, Braghiroli
D, Giampietro R, Animati F, Urbani A, Del Boccio P, Minotti
G (2004) Oxidative degradation of cardiotoxic anticancer anthracyclines
to phthalic acids : Novel function for ferrylmyoglobin? J. Biol.
Chem. 279:5088-5099. |
| 4 |
Sacco G, Giampietro R, Salvatorelli E, Menna
P, Bertani N, Graiani G, Animati F, Goso G, Maggi CA,
Mancini S, Minotti G (2003). Chronic cardiotoxicity of anticancer
anthracyclines in the rat : Role of secondary alcohol metabolites
and reduced toxicity by a novel anthracycline with impaired metabolite
formation and reactivity Br J Pharmacol 139:641-651. |
| 5 |
Minotti G, Ronchi R, Salvatorelli E, Menna
P, Cairo AG (2001). Doxorubicin irreversibly inactivates Iron Regulatory
Proteins 1 and 2 in cardiomyocytes : Evidence for distinct metabolic
pathways and implications for iron-mediated cardiotoxicity of antitumor
therapy. Cancer Res 61:8422-8428. |
| 6 |
Minotti G, Parlani M, Salvatorelli E, Menna
P, Cipollone A, Animati F, Maggi CA, Manzini S (2001). Impairment
of myocardial contractility by anticancer anthracyclines : Role
of secondary alcohol metabolites and evidence of reduced toxicity
by a novel disaccharide analogue. Br J Pharmacol 134:1271-1280. |
| 7 |
Minotti G, Saponiero S, Licata S, Menna P, Calafiore
AM, Teodori G, Gianni L (2001). Paclitaxel and docetaxel enhance
the metabolism of doxorubicin to toxic species in human myocardium.
Clin Cancer Res 7:1511-1515. |
|