RESEARCH GROUP MEMBERS
1 Pierluigi Navarra
2 Giacomo Pozzoli
3 Giuseppe Tringali
4 Cinzia Dello Russo
5 Alessandro Capuano
6 Alessia Proietti
7 Maria Laura De Simone
AFFILIATION
1 Institute of Pharmacology - Catholic University Medical School
GROUP DATA
Address Largo Francesco Vito 1 – 00168 Rome, Italy
Phone +39-0630154367
Fax +39-06233235103
E-mail pnavarra@rm.unicatt.it
Web Site  
RESEARCH TOPICS
1 In vitro models of rat glial cells to investigate issues in neuropharmacology and neurotoxicology
2 Citokines and growth factors: neuroimmunological aspects
3 Corticotrophin-releasing hormone (CRH) and cell growth of endocrine-related cancers
4 CNS drugs and the control of CRH gene expression and release
5 Endothelins and fever
ASSISTANCE ACTIVITIES
1 Monitoring of drug plasma levels for in-patients (Policlinico ‘A. Gemelli’ – Roma) and out-patients
2 Pharmacovigilance of ADR, Policlinico ‘A. Gemelli’ – Roma
EDUCATION IN TOXICOLOGY
1 Pre-clinical and clinical toxicology lessons for medical and biotechnology students
COLLABORATIONS
1 Dept. of Endocrinology, St. Bartholomew’s Hospital, University of London UK
2 The Clayton Foundation Laboratories for Peptide Biology. The Salk Institute, La Jolla, CA, USA
3 Dept. of Anaesthesiology, Neuroanesthesia Research, University of Illinois at Chicago, USA
4 Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil
PUBLICATIONS
1 Tringali G, Pozzoli G, Vairano M, Mores N, Preziosi P, Navarra P. (2005) Interleukin-18 displays effects opposite to those of interleukin-1 in the regulation of neuroendocrine stress axis. J Neuroimmunol. 160: 61-67.
2 Fabricio ASC, Tringali G, Pozzoli G and Navarra P. (2005) Mirtazapine acutely inhibits basal and K+-stimulated release of corticotropin-releasing hormone from the rat hypothalamus via a non-genomic mechanism. Psychopharmacology 178: 78-82.
3 Fabricio A, Veiga F, Cristofoletti R, Navarra P, Souza G. (2005) The effects of selective and non-selective cyclooxygenase inhibitors on endothelin-1-induced fever in rats. Am. J. Physiol. 288: R671-677.
4 Palozza P, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Calviello G. (2005) beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. J Nutr 135:129-136.
5 Calviello G, Di Nicuolo F, Gragnoli S, Piccioni E, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Palozza P. (2004) n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/ PGE2 induced ERK-1 and -2 and HIF-1{alpha} induction pathway. Carcinogenesis 25: 2303-2310.
6 Tringali G, Aubry JM, Moscianese K, Zamori C, Vairano M, Preziosi P, Navarra P and Pozzoli G. (2004) Valproic acid inhibits corticotropin releasing factor (CRF) synthesis and release from the rat hypothalamus in vitro: evidence for the involvement of GABA-ergic neurotransmission. J Psychiatry Neurosci 29: 459-466.
7 Vairano M, Graziani G, Tentori L, Tringali G, Navarra P and Dello Russo C. (2004) Primary cultures of microglial cells for testing toxicity of anticancer drugs. Toxicol Lett 148: 911-914.
  Ultimo aggiornamento: Dicembre 2005