Biochemical
Toxicology Group within the Unit
‘Mechanisms of Toxicity’ |
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| RESEARCH GROUP MEMBERS |
| 1 |
Emanuela Testai |
| 2 |
Simonetta Gemma |
| 3 |
Emma Di Consiglio |
| 4 |
Franca Maria Buratti |
| 5 |
Giovanna De Angelis |
| 6 |
Tiziana Catone |
| 7 |
Susanna Vichi |
| 8 |
Claudia Leoni |
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| AFFILIATION |
| 1 |
Istituto Superiore di Sanità – Department of
Environment and Primary Prevention |
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| GROUP DATA |
| Address |
Viale Regina Elena, 299- 00161 Roma |
| Phone |
+39-0649902920 |
| Fax |
+39-0649387139 |
| E-mail |
testai@iss.it |
| Web Site |
www.iss.it |
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| RESEARCH TOPICS |
| 1 |
Enzymology of drug-metabolizing enzymatic systems |
| 2 |
Biotrasformation, toxicokinetics and toxicity
of xenobiotics |
| 3 |
Molecular mechanisms of toxicity and cancerogenicity
of chemicals |
| 4 |
Biomarkers of individual susceptibility to
toxic compounds Analysis of polymorphic enzymes through genotyping/phenotyping
techniques |
| 5 |
Mechanisms of interactions between drugs and
chemicals |
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| SERVICES |
| 1 |
Involvement in Regulatory Activities on Toxicology
within the Istituto Superiore di Sanità |
| 2 |
GLP Inspector since 1997 (area of expertise:
Metabolism and Toxicokinetics) |
| 3 |
Assessor of the toxicological dossiers submitted
for registration to National and International Committees (member
as an expert of metabolism, toxicokinetics and toxicity) including:
National Committee for Plant Protection Products (since 2000)
FLAVIS Working Group (EFSA) on Flavouring Risk Evaluation (previous
SCOOP/FLAV) since 2001
Working Group for the Risk Assessment of Existing Chemicals - EU
Reg. 73/93/CE since 1998
National Committee for Biocides (since 2003):
OECD Test Guidelines Program (since 1998);
Scientific Committee ‘Health and Environmental Risk’ SC-HER within
EU DG SANCO since 2004 |
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| EDUCATION IN TOXICOLOGY |
| 1 |
Toxicological Analysis at the University of
Rome ‘La Sapienza’ – Faculty of Pharmacy- Environmental
Toxicology Course |
| 2 |
Teacher at Scuola Superiore di S.Anna (Pisa)
- Master in Environmental Risk Assessment and Management |
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| COLLABORATIONS |
| 1 |
Dipartimento Farmaco Istituto Superiore di
Sanità- Roma Italy (Meneguz, Traina) |
| 2 |
Dipartimento Ambiente e Prevenzione Primaria
- Istituto Superiore di Sanità (De Felip, Stammati, Funari, Dogliotti). |
| 3 |
Dipartimento di Sanità Animale Istituto Superiore
di Sanità- Roma Italy (Mantovani) |
| 4 |
Dipartimento di Neuroscienze Istituto Superiore
di Sanità- Roma Italy (Calamandrei, Laviola,) |
| 5 |
Center for Applied Biomedical Research (CRBA),
S. Orsola-Malpighi University Hospital, Bologna, Italy (Chieco) |
| 6 |
Molecular and Nutritional Epidemiology Unit,
Cancer Research and Prevention Center (CSPO), ScientificInstitute
of Tuscany, Florence, Italy (Palli) |
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| PUBLICATIONS |
| 1 |
F.M. Buratti, A. D'Aniello, M.T. Volpe, A.
Meneguz and E. Testai Malathion bioactivation in the human liver:
the contribution of different P450 isoforms. Drug Metab. Dispos.,
33, 295-302 (2005). |
| 2 |
E. Di Consiglio, A Meneguz and E. Testai Organophosphorothionate
pesticides inhibit the bioactivation of imipramine by human hepatic
cytochrome P450s. Toxicol. Appl. Pharmacol., 205, 237-246
(2005). |
| 3 |
D. Palli, C. Saieva, S. Gemma, G. Masala, M.
J. Gomez-Miguel, I. Luzzi, M. D'Errico, G. Matullo, G. Ozzola, F.
Sera, I. Zanna, E. Dogliotti and E. Testai GSTT1 and GSTM1 gene
polymorphisms and gastric cancer in a high-risk Italian population.
Int. J. Cancer 115, 284-289 (2005). |
| 4 |
P. Ade, S. Scardala, E. Testai e E. Funari
I cianobatteri in "Qualità degli ambienti acquatici
e implicazioni sanitarie" P. Ade e E. Funari (Eds.) Pitagora
Editrice-BO (I), pp. 123-156 (2005). |
| 5 |
S. Gemma, E. Testai, P. Chieco, L. Vittozzi
The bioactivation, toxicokinetics and acute effects of chloroform
in Fisher 344 and Osborne Mendel male rats. J. Appl. Toxicol.,
24, 203-210 (2004). |
| 6 |
Zucco F, De Angelis I, Testai E, Stammati A
(2004) Toxicology investigation with cell culture systems: 20 years
after, Toxicol in Vitro 18:153-163. |
| 7 |
Gemma S, Vittozzi L, Testai E (2003). Metabolism
of chloroform in the human liver and identification of the competent
P450s. Drug Metab Dispos 31:266-274. |
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